Jerry Seinfeld è un comico newyorkese dalla personalità nevrotica. Nelle vicende quotidiane, è accompagnato dall'amico George Costanza, sempre sull'orlo della bancarotta e un disastro con le donne, il bizzarro vicino Cosmo Kramer ed Elaine, ex fidanzata di Jerry e sua migliore amica.
George's involuntary winking is misinterpreted by many, and prompts Kramer to seek a favor from Yankee Paul O'Neill; Jerry tries to hide his distaste for meat from Elaine's cousin.
George's parents meet Susan's; Elaine fears her enthusiasm may have scared off the musician she's dating; Kramer drives a hansom cab, but feeds his steed bad fuel.
Elaine suspects a co-worker is faking a hearing impairment; Jerry makes a faux pas at the Friars Club after comic Pat Cooper sponsors him for membership.