Jerry Seinfeld è un comico newyorkese dalla personalità nevrotica. Nelle vicende quotidiane, è accompagnato dall'amico George Costanza, sempre sull'orlo della bancarotta e un disastro con le donne, il bizzarro vicino Cosmo Kramer ed Elaine, ex fidanzata di Jerry e sua migliore amica.
While doing his stand up act, Jerry takes questions from the crowd. One of the questions is "where did the series come from?" An often asked question, Jerry responds by showing a videotape he's prepared. The video includes his first appearance on "The Tonight Show" (6 May 1981), interviews with his managers, his co-creator Larry David, executives from NBC and Castle Rock, his fellow cast mates, and other people involved with the production during the early years (the pilot through season. All of this is interspersed with numerous clips from the show. At the end when asked if they are going to do a reunion show, Jerry answers "Ah yes, you've just saw it, I hope you enjoyed it." This is followed by several bloopers.